44/1-21(37)+169(80-80)+(25-24)*5

First, we need to calculate the operations within the parentheses:

3*7 = 21
80-80 = 0
25-24 = 1

Now substitute these values back into the expression:

44/1 - 2121 + 1690 + 1*5

Simplify further:

44 - 441 + 0 + 5

Now, perform the remaining operations:

44 - 441 + 5 = -397

Therefore, the final answer is -397.