First, let's apply the multiplication operation within each pair of coordinates:

(0, 4) -2 = (0-2, 4-2) = (0, -8)
(2, 5) -4 = (2-4, 5-4) = (-8, -20)
(0, 16) -5 = (0-5, 16-5) = (0, -80)
(6, 25) -3 = (6-3, 25-3) = (-18, -75)

Now we have:

(0, -8) - (8, -20) = (0+8, -8+20) = (8, 12)
(8, 12) - (0, -80) = (8-0, 12-(-80)) = (8, 92)
((8, 92) 5) = (85, 925) = (40, 460)
((6, 25) -3) 2 = (-18, -75) 2 = (-182, -752) = (-36, -150)

Therefore, the final result is:

(40, 460) - (-36, -150) = (40+36, 460+150) = (76, 610)