Present simple:

My sister flies to Italy every year.

Question: Does your sister fly to Italy every year?

Present continuous:

My sister is flying to Italy now.

Question: Is your sister flying to Italy now?

Past simple:

My sister flew to Italy last year.

Question: Did your sister fly to Italy last year?

Present perfect:

My sister has flown to Italy before.

Question: Has your sister flown to Italy before?

Future simple:

My sister will fly to Italy next year.

Question: Will your sister fly to Italy next year?