4(-1/9) - 2(8(-1/9) - 5(1/8)) + 3(2(1/8) + (-1/9) - 3)
= -4/9 - 2(-32/9 - 5/8) + 3(1/4 - 1/9 - 3)
= -4/9 + 64/9 + 5/4 + 3/9 - 9
= 65/9 + 5/4 - 24/9
= 65/9 + 45/36 - 96/36
= 65/9 - 51/36
= (260 - 459) / 36
= -199/36

Поэтому, ответ: -199/36