To solve this expression, we can follow the order of operations (PEMDAS).

10 - 33/4 * (2 + 1/3 + 1 + 2/5) / 1 + 5/9

First, we need to simplify the inner parentheses.

= 10 - 33/4 (2 + 16/15) / 1 + 5/9
= 10 - 33/4 (30/15 + 16/15) / 1 + 5/9
= 10 - 33/4 * (46/15) / 1 + 5/9

Next, we need to simplify the multiplication and division.

= 10 - 33/4 (46/15) / 1 + 5/9
= 10 - 33/4 46/15 + 5/9
= 10 - (3346)/(415) + 5/9
= 10 - 1518/60 + 5/9
= 10 - 253/10 + 5/9
= 90/9 - 253/10 + 5/9
= (810 - 253 + 50)/90
= 607/90

Therefore, the simplified expression is 607/90.