Let's simplify the equation step by step:

18 + 4(1-4x) = -4(1,1-2x)

18 + 4 - 16x = -4(1,1-2x)

22 - 16x = -4 + 8x

Combine like terms:

22 + 4 = 8x - 16x

26 = -8x

Divide both sides by -8:

x = -26/8

Simplify:

x = -13/4

Therefore, the solution to the equation 18 + 4(1-4x) = -4(1,1-2x) is x = -13/4.