To simplify the given expression, we need to divide each term on the top by each term on the bottom.

So,

(5x^2-3x-2)/(5xy+2y-10x-4)
= (5x^2/(5xy) - 3x/(5xy) - 2/(5xy)) / (1 + (2y)/(5xy) - (10x)/(5xy) - 4/(5xy))
= (x/ y - 3/(5y) - 2/(5xy)) / (1 + 2/(5x) - 10/(5y) - 4/(5xy))
= (x/ y - 3/(5y) - 2/(5xy)) / (1 + 2/(5x) - 2y/y - 4/(5xy))
= (x/ y - 3/(5y) - 2/(5xy)) / (1 + 2/(5x) - 2/y - 4/(5xy))
= (x/ y - 3/(5y) - 2/(5xy)) / (1 + 2/(5x) - 2/y - 4/(5xy))

Therefore, the simplified form of the given expression is (x/y - 3/(5y) - 2/(5xy)) / (1 + 2/(5x) - 2/y - 4/(5xy)).